Prof. Dr. Charlotte Förster
Lehrstuhlleitung/Chair
➯ D0 09
✆ +49 931 31-+49 031 31-88823
charlotte.foerster@biozentrum.uni-wuerzburg.de

Forschungsinteresse

Mein Hauptinteresse ist es, die Funktionsweise von inneren Uhren auf molekularer und neuronaler Ebene zu verstehen sowie aufzuklären wie innere Uhren auf die zyklischen Änderungen der Umwelt synchronisiert werden und wie sie Verhalten steuern. Da die Funktion von inneren Uhren im Tierreich stark konserviert ist, eignet sich die Taufliege Drosophila melanogaster ihrer genetischen Zugänglichkeit am besten dazu, die meisten dieser Fragen zu untersuchen. In vergleichenden Studien untersuchen wir das neuronale Netzwerk der inneren Uhr von anderen Insekten. Außerdem sind wir an den Interaktionen zwischen chronischem psychosozialem Stress und der inneren Uhr bei Säugetieren interessiert (Modellsystem Maus).

Spezifische Interessen sind:

  1. Die Rolle von Neuropeptiden im Uhrnetzwerk von Drosophila melanogaster und anderen Insektenarten
  2. Die Rolle von Rhodopsinen und von Cryptochrom in der Sycnrhonisation der Uhr auf natürliche Licht-Dunkel Zyklen
  3. Organisation der Inneren Uhr bei sozialen Insekten
  4. Die Rolle von Dopamin, Serotonin und von Gliazellen bei der Schlafregulation
  5. Der Zusammenhang zwischen psychosozialem Stress und der Inneren Uhr

Awards & Fundings

Awards

2014: Die Karl-Ritter-von-Frisch-Medaille.

2012: Chaire Joliot at the Laboratoire de Neurobiologie, ESPCI ParisTech

2011: Ariens-Kappers Medallion der „European Biological Rhythms Society”

2008: SRBR Member (Society of Biological Rhythm Research) at Large

2005: Aschoff-Honma Preis der japanischen Stiftung „Honma Foundation of Life Science“ in Anerkennung eines herausragenden Beitrags auf dem Wissenschaftsgebiet Biologische Rhythmik

2003: Verleihung von Aschoff’s Ruler

2000: Forschungsstipendium der Deutschen Forschungsgemeinschaft

1998: Margarete von Wrangell Habilitationsstipendium

1996: Forschungsstipendium der Deutschen Forschungsgemeinschaft

1986: Attempto-Preis der Universität Tübingen für neurobiologische Forschung

Fundings

DFG:

2013: SFB 1047 Insect Timing Projects A1, A2, A3 and C5
 
2013: Fo 207/14-1: Interaktion von monoaminergen Neuronen, Gliazellen und circadianen Uhrneuronen bei der Kontrolle des Schlafwachverhaltens der Taufliege Drosophila melanogaster

2011-2013: Fo 207/13-1: Wechselwirkungen zwischen chronischem psychosozialen Stress und der Inneren Uhr

2011-2013: Fo 207/12-1: Die Rolle von Neuropeptiden in der Inneren Uhr von Drosophila

2010-2012: SFB 581/TPB28: Störungen im Schlaf-Wach-Verhalten verursacht durch Transmissionsdefekte an dopaminergen und serotonrgen Tripartit Synapsen.

2007-2012: Fo 207/10-3: Synchronisation der Aktivitätsrhythmik und der Schrittmacher-Neuronen von Drosophila melanogaster durch Licht und Temperatur

2003-2009: Fo 207/9-1,2: Verschaltung circadianer Schrittmacherneuronen im Gehirn von Drosophila melanogaster und Mechanismen des Transports und der Sekretion des Neuropeptids „Pigment dispersing Factor“ (PDF)

2002-2009: GK 640: Sensorische Photorezeptoren in natürlichen und künstlichen Systemen

 GIF (German Israeli Foundation):

2006-2010: No. I-822-73.1/2004: Aufgaben-spezifische chronobiologische Plastizität plasticity links the circadian clock to social organization in bees. In cooperation with Prof. Dr. Guy Bloch (Jerusalem)

 EU:

2012: Marie Curie Project FP7-People-2012-ITN Titel:  "INsecTIME"

2007-2011: Integrated Project # 018741 (LSHM-CT-2006) “EUCLOCK” Synchronisation der Inneren Uhr.

Curriculum Vitae

download (PDF)

Publikationen

Artikel

  • Joschinski, J., Beer, K., Helfrich-Förster, C., and Krauss, J. (2016) Pea Aphids (Hemiptera: Aphididae) Have Diurnal Rhythms When Raised Independently of a Host Plant, Journal of Insect Science 16, 32.
     
  • Robin Fischer, C. H. -F. (2016) GSK-3 Beta Does Not Stabilize Cryptochrome in the Circadian Clock of Drosophila, PloS one.
     
  • Chen, J., Reiher, W., Hermann-Luibl, C., Sellami, A., Cognigni, P., Kondo, S., Helfrich-F\"orster, C., Veenstra, J. A., and Wegener, C. (2016) Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF, PLOS Genet 12, e1006346.
     
  • Eck, S., Helfrich-Förster, C., and Rieger, D. (2016) The timed depolarization of morning and evening oscillators phase shifts the circadian clock of Drosophila JBR, Journal of Biological Rhythms.
     
  • Yoshii, T., Hermann-Luibl, C., and Helfrich-Förster, C. (2016) Circadian light-input pathways in Drosophila, Communicative \& Integrative Biology 9, e1102805.
     
  • Beer, K., Steffan-Dewenter, I., Härtel, S., and Helfrich-Förster, C. (2016) A new device for monitoring individual activity rhythms of honey bees reveals critical effects of the social environment on behavior, J Comp Physiol A 1--11.
     
  • Schlichting, M., Menegazzi, P., Lelito, K. R., Yao, Z., Buhl, E., Dalla Benetta, E., Bahle, A., Denike, J., Hodge, J. J., Helfrich-F\"orster, C., and others,. (2016) A Neural Network Underlying Circadian Entrainment and Photoperiodic Adjustment of Sleep and Activity in Drosophila, The Journal of Neuroscience 36, 9084--9096.
     
  • Vaze, K. M., and Helfrich-F\"orster, C. (2016) Drosophila ezoana uses an hour-glass or highly damped circadian clock for measuring night length and inducing diapause, Physiological Entomology.
     
  • Senthilan, P. R., and Helfrich-F\"orster, C. (2016) Rhodopsin 7--The unusual Rhodopsin in Drosophila, PeerJ 4, e2427.
     
  • Schlichting, M., and Helfrich-Förster, C. (2015) Chapter Five - Photic Entrainment in Drosophila Assessed by Locomotor Activity Recordings. In Circadian Rhythms and Biological Clocks, Part B (Sehgal, A., Ed.), pp 105 - 123, Academic Press.
     
  • Schlichting, M., Grebler, R., Menegazzi, P., and Helfrich-F\"orster, C. (2015) Twilight Dominates Over Moonlight in Adjusting Drosophila’s Activity Pattern, Journal of biological rhythms, SAGE Publications 30, 117--128.
     
  • Chouhan, N.  S., Wolf, R., Helfrich-Förster, C., and Heisenberg, M. (2015) Flies Remember the Time of Day, Current Biology 25, 1619 - 1624.
     
  • Hermann-Luibl, C., and Helfrich-Förster, C. (2015) Clock network in Drosophila, Current Opinion in Insect Science 7, 65 - 70.
     
  • Yoshii, T., Hermann-Luibl, C., Kistenpfennig, C., Schmid, B., Tomioka, K., and Helfrich-F\"orster, C. (2015) Cryptochrome-Dependent and-Independent Circadian Entrainment Circuits in Drosophila, The Journal of Neuroscience, Soc Neuroscience 35, 6131--6141.
     
  • Bartlang, M. S., Oster, H., and Helfrich-Förster, C. (2015) Repeated Psychosocial Stress at Night Affects the Circadian Activity Rhythm of Male Mice, Journal of Biological Rhythms 30, 228-241.
     
  • Schlichting, M., Menegazzi, P., and Helfrich-F\"orster, C. (2015) Normal vision can compensate for the loss of the circadian clock. In Proc. R. Soc. B, p 20151846, The Royal Society.
     
  • Kmoch, S., Majewski, J., Ramamurthy, V., Cao, S., Fahiminiya, S., Ren, H., MacDonald, I. M., Lopez, I., Sun, V., Keser, V., Helfrich-Förster, C., and others,. (2015) Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness, Nature communications, Nature Publishing Group 6.
     
  • Dusik, V., Senthilan, P. R., Mentzel, B., Hartlieb, H., W\"ulbeck, C., Yoshii, T., Raabe, T., and Helfrich-F\"orster, C. (2015) The MAP Kinase p38 Is Part of Drosophila melanogaster's Circadian Clock, PLoS Genetics 10.
     
  • Hermann-Luibl, C., Yoshii, T., Senthilan, P. R., Dircksen, H., and Helfrich-F\"orster, C. (2014) The ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster, The Journal of Neuroscience, Soc Neuroscience 34, 9522--9536.
     
  • Bartlang, M. S., Savelyev, S. A., Johansson, A. -S., Reber, S. O., Helfrich-F\"orster, C., and Lundkvist, G. B. S. (2014) Repeated psychosocial stress at night, but not day, affects the central molecular clock, Chronobiology international, Taylor \& Francis 31, 996--1007.
     
  • Helfrich-F\"orster, C. (2014) From neurogenetic studies in the fly brain to a concept in circadian biology, Journal of neurogenetics, Taylor \& Francis 28, 329--347.
     
  • Schlichting, M., Grebler, R., Peschel, N., Yoshii, T., and Helfrich-F\"orster, C. (2014) Moonlight detection by Drosophila’s endogenous clock depends on multiple photopigments in the compound eyes, Journal of biological rhythms, SAGE Publications 29, 75--86.
     
  • Hermann, C., Saccon, R., Senthilan, P. R., Domnik, L., Dircksen, H., Yoshii, T., and Helfrich-F\"orster, C. (2013) The circadian clock network in the brain of different Drosophila species, Journal of Comparative Neurology, Wiley Online Library 521, 367--388.
     
  • Gmeiner, F., Ko\lodziejczyk, A., Yoshii, T., Rieger, D., N\"assel, D. R., and Helfrich-F\"orster, C. (2013) GABAB receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster, The Journal of experimental biology, The Company of Biologists Ltd 216, 3837--3843.
     
  • Ahmed, Z., and Helfrich-F\"orster, C. (2013) DroLIGHT: Real Time Embedded System towards Endogenous Clock Synchronization of Drosophila. In Front Neuroinform Conference Abstract: Neuroinformatics.
     
  • Hermann, C., Saccon, R., Senthilan, P. R., Domnik, L., Dircksen, H., Yoshii, T., and Helfrich-Förster, C. (2013) The circadian clock network in the brain of different Drosophila species, Journal of Comparative Neurology, Wiley Subscription Services, Inc., A Wiley Company 521, 367--388.
     
  • Kronfeld-Schor, N., Dominoni, D., de la Iglesia, H., Levy, O., Herzog, E. D., Dayan, T., and Helfrich-Förster, C. (2013) Chronobiology by moonlight, Proceedings of the Royal Society of London B: Biological Sciences, The Royal Society 280.
     
  • Menegazzi, P., Vanin, S., Yoshii, T., Rieger, D., Hermann, C., Dusik, V., Kyriacou, C. P., Helfrich-F\"orster, C., and Costa, R. (2013) Drosophila clock neurons under natural conditions, Journal of biological rhythms, SAGE Publications 28, 3--14.
     
  • Mazzotta, G., Rossi, A., Leonardi, E., Mason, M., Bertolucci, C., Caccin, L., Spolaore, B., Martin, A. J. M., Schlichting, M., Grebler, R., Helfrich-Förster, C., Mammi, S., Costa, R., and Tosatto, S. C. E. (2013) Fly cryptochrome and the visual system, Proceedings of the National Academy of Sciences 110, 6163-6168.
     
  • Ahmed, Z., Helfrich-Förster, C., and Dandekar, T. (2013) Integrating Formal UML Designs and HCI Patterns with Spiral SDLC in DroLIGHT Implementation, Recent Patents on Computer Science 6, 85-98.
     
  • Kauranen, H., Menegazzi, P., Costa, R., Helfrich-F\"orster, C., Kankainen, A., and Hoikkala, A. (2012) Flies in the North Locomotor Behavior and Clock Neuron Organization of Drosophila montana, Journal of biological rhythms, SAGE Publications 27, 377--387.
     
  • Rieger, D., Peschel, N., Dusik, V., Glotz, S., and Helfrich-Förster, C. (2012) The Ability to Entrain to Long Photoperiods Differs between 3 Drosophila melanogaster Wild-Type Strains and Is Modified by Twilight Simulation, Journal of Biological Rhythms 27, 37-47.
     
  • Vieira, J., Jones, A. R., Danon, A., Sakuma, M., Hoang, N., Robles, D., Tait, S., Heyes, D. J., Picot, M., Yoshii, T., Helfrich-Förster, C., and others,. (2012) Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability, PloS one, Public Library of Science 7, e31867--e31867.
     
  • Menegazzi, P., Yoshii, T., and Helfrich-Förster, C. (2012) Laboratory versus Nature: The Two Sides of the Drosophila Circadian Clock, Journal of Biological Rhythms 27, 433-442.
     
  • Bartlang, M. S., Neumann, I. D., Slattery, D. A., Uschold-Schmidt, N., Kraus, D., Helfrich-Förster, C., and Reber, S. O. (2012) Time matters: pathological effects of repeated psychosocial stress during the active, but not inactive, phase of male mice, Journal of Endocrinology 215, 425-437.
     
  • Hermann, C., Yoshii, T., Dusik, V., and Helfrich-Förster, C. (2012) Neuropeptide F immunoreactive clock neurons modify evening locomotor activity and free-running period in Drosophila melanogaster, The Journal of Comparative Neurology, Wiley Subscription Services, Inc., A Wiley Company 520, 970--987.
     
  • Bywalez, W., Menegazzi, P., Rieger, D., Schmid, B., Helfrich-F\"orster, C., and Yoshii, T. (2012) The dual-oscillator system of Drosophila melanogaster under natural-like temperature cycles, Chronobiology international, Taylor \& Francis 29, 395--407.
     
  • Kistenpfennig, C., Hirsh, J., Yoshii, T., and Helfrich-Förster, C. (2012) Phase-Shifting the Fruit Fly Clock without Cryptochrome, Journal of Biological Rhythms 27, 117-125.
     
  • Yoshii, T., Rieger, D., and Helfrich-Förster, C. (2012) Chapter 4 - Two clocks in the brain: An update of the morning and evening oscillator model in Drosophila. In The Neurobiology of Circadian Timing (Andries Kalsbeek, M. M., and Foster, R. G., Eds.), pp 59 - 82, Elsevier.
     
  • Umezaki, Y., Yoshii, T., Kawaguchi, T., Helfrich-Förster, C., and Tomioka, K. (2012) Pigment-Dispersing Factor Is Involved in Age-Dependent Rhythm Changes in Drosophila melanogaster, Journal of Biological Rhythms 27, 423-432.
     
  • Helfrich-Förster, C., Nitabach, M. N., Holmes, T. C., and others,. (2011) Insect circadian clock outputs, Essays in biochemistry, Portland Press Ltd. 49, 87--101.
     
  • Schmid, B., Helfrich-Förster, C., and Yoshii, T. (2011) A New ImageJ Plug-in “ActogramJ” for Chronobiological Analyses, Journal of Biological Rhythms 26, 464-467.
     
  • Peschel, N., and Helfrich-Förster, C. (2011) Setting the clock – by nature: Circadian rhythm in the fruitfly Drosophila melanogaster, \FEBS\ Letters 585, 1435 - 1442.
     
  • Helfrich-Förster, C. (2010) Das neuronale Netzwerk der Inneren Uhr, Neuroforum 16, 151.
     
  • Ritz, T., Yoshii, T., Helfrich-Förster, C., and Ahmad, M. (2010) Cryptochrome: A photoreceptor with the properties of a magnetoreceptor, Communicative \& integrative biology, Taylor \& Francis 3, 24--27.
     
  • Yoshii, T., Hermann, C., and Helfrich-Förster, C. (2010) Cryptochrome-Positive and -Negative Clock Neurons in Drosophila Entrain Differentially to Light and Temperature, Journal of Biological Rhythms 25, 387-398.
     
  • Benna, C., Bonaccorsi, S., Wülbeck, C., Helfrich-Förster, C., Gatti, M., Kyriacou, C. P., Costa, R., and Sandrelli, F. (2010) Drosophila timeless2 Is Required for Chromosome Stability and Circadian Photoreception, Current Biology 20, 346 - 352.
     
  • Johard, H. A. D., Yoishii, T., Dircksen, H., Cusumano, P., Rouyer, F., Helfrich-Förster, C., and Nässel, D. R. (2009) Peptidergic clock neurons in Drosophila: Ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons, The Journal of Comparative Neurology, Wiley Subscription Services, Inc., A Wiley Company 516, 59--73.
     
  • W\"ulbeck, C., Grieshaber, E., and Helfrich-F\"orster, C. (2009) Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way, Chronobiology international, Taylor \& Francis 26, 1307--1322.
     
  • Helfrich-Förster, C. (2009) Macht die innere Uhr “mondsüchtig”?, BIOspektrum 5, 491-492.
     
  • Yoshii, T., Vanin, S., Costa, R., and Helfrich-Förster, C. (2009) Synergic Entrainment of Drosophila’s Circadian Clock by Light and Temperature, Journal of Biological Rhythms 24, 452-464.
     
  • Yoshii, T., W\"ulbeck, C., Sehadova, H., Veleri, S., Bichler, D., Stanewsky, R., and Helfrich-F\"orster, C. (2009) The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock, The Journal of Neuroscience, Soc Neuroscience 29, 2597--2610.
     
  • Yoshii, T., Ahmad, M., and Helfrich-Förster, C. (2009) Cryptochrome Mediates Light-Dependent Magneto-sensitivity of Drosophila's Circadian Clock, PLoS biology 7, 813.
     
  • Kempinger, L., Dittmann, R., Rieger, D., and Helfrich-F\"orster, C. (2009) The nocturnal activity of fruit flies exposed to artificial moonlight is partly caused by direct light effects on the activity level that bypass the endogenous clock, Chronobiology international, Taylor \& Francis 26, 151--166.
     
  • Helfrich-Förster, C. (2009) Does the Morning and Evening Oscillator Model Fit Better for Flies or Mice?, Journal of Biological Rhythms 24, 259-270.
     
  • Helfrich-Förster, C., Yoshii, T., Vanin, S., and Costa, R. (2009) The role of PDF in the circadian clock, Sleep Biol Rhythms 7, 130-143.
     
  • Rieger, D., Wülbeck, C., Rouyer, F., and Helfrich-Förster, C. (2009) Period Gene Expression in Four Neurons Is Sufficient for Rhythmic Activity of Drosophila melanogaster under Dim Light Conditions, Journal of Biological Rhythms 24, 271-282.
     

Ältere Artikel

Opens internal link in current window1983 - 2008

Buchbeiträge (peer reviewed)

  • Helfrich-Förster C and Engelmann W (2002) Photoreceptors for the circadian clock of the fruit fly. In: Circadian Rhythms (V. Kumar, ed.), Narosa Publishing House, 94-106.
  • Helfrich-Förster C (2006) Immunohistochemistry in Drosophila, sections and whole mount. In: Methods in Molecular Biology, Volume 362, 533-547.
  • Wülbeck C and Helfrich-Förster C (2006) RNA In Situ hybridizations on Drosophila whole mounts. In: Methods in Molecular Biology, Volume 362, 495-511.
  • Helfrich-Förster C, Yoshii T, Wülbeck C, Grieshaber E, Rieger D, Bachleitner B, Cusamano P, Rouyer F (2007) The Lateral and Dorsal Neurons of Drosophila melanogaster: New insights about their morphology and function. In: Clocks and Rhythms, Cold Spring Harbor Laboratory Press, 517-525.
  • Yoshii T, Rieger D, Helfrich-Förster C (2012) Two clocks in the brain – an update of the Morning and Evening oscillator model in Drosophila. In: In Andries Kalsbeek, Martha Merrow, Till Roenneberg and Russell G. Foster, editors: Progress in Brain Research, Vol. 199, Neurobiology of Circadian Timing. Amsterdam, The Netherlands, pp. 59-82.
  • Johnsson A, Helfrich-Förster C, Engelmann W (2015) How light resets circadian clocks. In Photobiology. The Science of Light and Life. Editor: Lars Olof Björn. Third edition. Springer, New York, pp 243-297.

Sonstige

  • Förster C (2009) Macht die innere Uhr “mondsüchtig”? BIOspektrum 5, 491-492.
  • Helfrich-Förster C (2010) Das neuronale Netzwerk der Inneren Uhr. Neuroforum 1/10, 151-156.
  • Helfrich-Förster (2015) Die Innere Uhr von Mensch und Tier. In Blickpunkt: Zeit. Die (un)ermessliche Dimension? (Hrsg: E.A. Herzog, H.-C. Bauer, K. P Überriegler), Books on demand. pp: 89-107. ISBN 9783734 785986.