Prof. Dr. Charlotte Förster
Lehrstuhlleitung/Chair
➯ D0 09
✆ +49 931 31-+49 031 31-88823
charlotte.foerster@biozentrum.uni-wuerzburg.de

Forschungsinteresse

Mein Hauptinteresse ist es, die Funktionsweise von inneren Uhren auf molekularer und neuronaler Ebene zu verstehen sowie aufzuklären wie innere Uhren auf die zyklischen Änderungen der Umwelt synchronisiert werden und wie sie Verhalten steuern. Da die Funktion von inneren Uhren im Tierreich stark konserviert ist, eignet sich die Taufliege Drosophila melanogaster ihrer genetischen Zugänglichkeit am besten dazu, die meisten dieser Fragen zu untersuchen. In vergleichenden Studien untersuchen wir das neuronale Netzwerk der inneren Uhr von anderen Insekten. Außerdem sind wir an den Interaktionen zwischen chronischem psychosozialem Stress und der inneren Uhr bei Säugetieren interessiert (Modellsystem Maus).

Spezifische Interessen sind:

  1. Die Rolle von Neuropeptiden im Uhrnetzwerk von Drosophila melanogaster und anderen Insektenarten
  2. Die Rolle von Rhodopsinen und von Cryptochrom in der Sycnrhonisation der Uhr auf natürliche Licht-Dunkel Zyklen
  3. Organisation der Inneren Uhr bei sozialen Insekten
  4. Die Rolle von Dopamin, Serotonin und von Gliazellen bei der Schlafregulation
  5. Der Zusammenhang zwischen psychosozialem Stress und der Inneren Uhr

Awards & Fundings

Awards

2014: Die Karl-Ritter-von-Frisch-Medaille.

2012: Chaire Joliot at the Laboratoire de Neurobiologie, ESPCI ParisTech

2011: Ariens-Kappers Medallion der „European Biological Rhythms Society”

2008: SRBR Member (Society of Biological Rhythm Research) at Large

2005: Aschoff-Honma Preis der japanischen Stiftung „Honma Foundation of Life Science“ in Anerkennung eines herausragenden Beitrags auf dem Wissenschaftsgebiet Biologische Rhythmik

2003: Verleihung von Aschoff’s Ruler

2000: Forschungsstipendium der Deutschen Forschungsgemeinschaft

1998: Margarete von Wrangell Habilitationsstipendium

1996: Forschungsstipendium der Deutschen Forschungsgemeinschaft

1986: Attempto-Preis der Universität Tübingen für neurobiologische Forschung

Fundings

DFG:

2013: SFB 1047 Insect Timing Projects A1, A2, A3 and C5
 
2013: Fo 207/14-1: Interaktion von monoaminergen Neuronen, Gliazellen und circadianen Uhrneuronen bei der Kontrolle des Schlafwachverhaltens der Taufliege Drosophila melanogaster

2011-2013: Fo 207/13-1: Wechselwirkungen zwischen chronischem psychosozialen Stress und der Inneren Uhr

2011-2013: Fo 207/12-1: Die Rolle von Neuropeptiden in der Inneren Uhr von Drosophila

2010-2012: SFB 581/TPB28: Störungen im Schlaf-Wach-Verhalten verursacht durch Transmissionsdefekte an dopaminergen und serotonrgen Tripartit Synapsen.

2007-2012: Fo 207/10-3: Synchronisation der Aktivitätsrhythmik und der Schrittmacher-Neuronen von Drosophila melanogaster durch Licht und Temperatur

2003-2009: Fo 207/9-1,2: Verschaltung circadianer Schrittmacherneuronen im Gehirn von Drosophila melanogaster und Mechanismen des Transports und der Sekretion des Neuropeptids „Pigment dispersing Factor“ (PDF)

2002-2009: GK 640: Sensorische Photorezeptoren in natürlichen und künstlichen Systemen

 GIF (German Israeli Foundation):

2006-2010: No. I-822-73.1/2004: Aufgaben-spezifische chronobiologische Plastizität plasticity links the circadian clock to social organization in bees. In cooperation with Prof. Dr. Guy Bloch (Jerusalem)

 EU:

2012: Marie Curie Project FP7-People-2012-ITN Titel:  "INsecTIME"

2007-2011: Integrated Project # 018741 (LSHM-CT-2006) “EUCLOCK” Synchronisation der Inneren Uhr.

Curriculum Vitae

download (PDF)

Publikationen

Artikel

  • Frenkel, L., Muraro, N. I., González, A. N. B., Marcora, M. S., Bernabó, G., Hermann-Luibl, C., Romero, J. I., Helfrich-Förster, C., Castaño, E. M., Marino-Busjle, C., Calvo, D. J., and Ceriani, M. F. (2017) Organization of Circadian Behavior Relies on Glycinergic Transmission, Cell Reports 19, 72-85.
     
  • Menegazzi, P., Benetta, E. D., Beauchamp, M., Schlichting, M., Steffan-Dewenter, I., and Helfrich-Förster, C. (2017) Adaptation of circadian neuronal network to photoperiod in high-latitude European Drosophilids, CURR BIOL 27, 833-839.
     
  • Benna, C., Helfrich-Förster, C., Rajendran, S., Monticelli, H., Pilati, P., Nitti, D., and Mocellin, S. (2017) Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis, Oncotarget.
     
  • Schlichting, M., Menegazzi, P., Lelito, K. R., Yao, Z., Buhl, E., Dalla Benetta, E., Bahle, A., Denike, J., Hodge, J. J., Helfrich-Förster, C., and others,. (2016) A neural network underlying circadian entrainment and photoperiodic adjustment of sleep and activity in Drosophila, J Neurosci 36, 9084-9096.
     
  • Beer, K., Steffan-Dewenter, I., Härtel, S., and Helfrich-Förster, C. (2016) A new device for monitoring individual activity rhythms of honey bees reveals critical effects of the social environment on behavior, J Comp Physiol A 202, 555-565.
     
  • Joschinski, J., Beer, K., Helfrich-Förster, C., and Krauss, J. (2016) Pea aphids (Hemiptera: Aphididae) have diurnal rhythms when raised independently of a host plant, J Insect Sci 16, 31.
     
  • Koch, C. E., Bartlang, M. S., Kiehn, J. T., Lucke, L., Naujokat, N., Helfrich-Förster, C., Reber, S. O., and Oster, H. (2016) Time-of-day-dependent adaptation of the HPA axis to predictable social defeat stress, J Endocrinol 231, 209-221.
     
  • Senthilan, P. R., and Helfrich-Förster, C. (2016) Rhodopsin 7--The unusual Rhodopsin in Drosophila, PeerJ 4, e2427.
     
  • Vaze, K. M., and Helfrich-Förster, C. (2016) Drosophila ezoana uses an hour-glass or highly damped circadian clock for measuring night length and inducing diapause, Physiol Entomol 41, 378-389.
     
  • Fischer, R., Helfrich-Förster, C., and Peschel, N. (2016) GSK-3 Beta does not stabilize cryptochrome in the circadian clock of Drosophila, PLOS ONE 11, 1-17.
     
  • Schlichting, M., Grebler, R., Menegazzi, P., and Helfrich-Förster, C. (2015) Twilight dominates over moonlight in adjusting Drosophila’s activity pattern, J Biol Rhythms 30, 117-128.
     
  • Chouhan, N.  S., Wolf, R., Helfrich-Förster, C., and Heisenberg, M. (2015) Flies remember the time of day, CURR BIOL 25, 1619-1624.
     
  • Kmoch, S., Majewski, J., Ramamurthy, V., Cao, S., Fahiminiya, S., Ren, H., MacDonald, I. M., Lopez, I., Sun, V., Keser, V., Khan, A., Str\'anecký, V., Hartmannov\'a, H., Přistoupilov\'a, A., Hodaňov\'a, K., Piherov\'a, L., Kuchař, L., Baxov\'a, A., Chen, R., Barsottini, O. G., Pyle, A., Griffin, H., Splitt, M., Sallum, J., Tolmie, J. L., Sampson, J. R., Chinnery, P., Canada, C. 4R., Banin, E., Sharon, D., Dutta, S., Grebler, R., Helfrich-Foerster, C., Pedroso, J. L., Kretzschmar, D., Cayouette, M., and Koenekoop, R. K. (2015) Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness, Nat Commun 6, 5614-5614.
     
  • Schlichting, M., Menegazzi, P., and Helfrich-Förster, C. (2015) Normal vision can compensate for the loss of the circadian clock, Proc R Soc Lond B: Biol Sci 282, 20151846.
     
  • Yoshii, T., Hermann-Luibl, C., Kistenpfennig, C., Schmid, B., Tomioka, K., and Helfrich-Förster, C. (2015) Cryptochrome-Dependent and -Independent Circadian Entrainment Circuits in Drosophila, J Neurosci 35, 6131--6141.
     
  • Hermann-Luibl, C., and Helfrich-Förster, C. (2015) Clock network in Drosophila, Curr Opin Insect Sci 7, 65-70.
     
  • Johnsson, A., Helfrich-F\"orster, C., and Engelmann, W. (2015) How light resets circadian clocks. In Photobiology, pp 243-297, Springer.
     
  • Schlichting, M., and Helfrich-Förster, C. (2015) Photic entrainment in Drosophila assessed by locomotor activity recordings. In Methods Enzymol, pp 105-123.
     
  • Schlichting, M., Grebler, R., Peschel, N., Yoshii, T., and Helfrich-Förster, C. (2014) Moonlight detection by Drosophila's endogenous clock depends on multiple photopigments in the compound eyes, J Biol Rhythms 29, 75-86.
     
  • Dusik, V., Senthilan, P. R., Mentzel, B., Hartlieb, H., Wülbeck, C., Yoshii, T., Raabe, T., and Helfrich-Förster, C. (2014) The MAP Kinase p38 Is Part of Drosophila melanogaster's Circadian Clock, PLoS Genet 10, 1-19.
     
  • Helfrich-Förster, C. (2014) From neurogenetic studies in the fly brain to a concept in circadian biology, J Neurogenet 28, 329-347.
     
  • Hermann-Luibl, C., Yoshii, T., Senthilan, P. R., Dircksen, H., and Helfrich-Förster, C. (2014) The ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster, J Neurosci 34, 9522-9536.
     
  • Mazzotta, G., Rossi, A., Leonardi, E., Mason, M., Bertolucci, C., Caccin, L., Spolaore, B., Martin, A. J. M., Schlichting, M., Grebler, R., Helfrich-Förster, C., and others,. (2013) Fly cryptochrome and the visual system, Proc Natl Acad Sci 110, 6163-6168.
     
  • Menegazzi, P., Vanin, S., Yoshii, T., Rieger, D., Hermann, C., Dusik, V., Kyriacou, C. P., Helfrich-Förster, C., and Costa, R. (2013) Drosophila clock neurons under natural conditions, J Biol Rhythms 28, 3-14.
     
  • Redondo, B. B., Bunz, M., Halder, P., Sadanandappa, M. K., Mühlbauer, B., Erwin, F., Hofbauer, A., Rodrigues, V., VijayRaghavan, K., Ramaswami, M., Rieger, D., Wegener, C., Helfrich-Förster, C., and Buchner, E. (2013) Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg Hybridoma Library, PLOS ONE 8, 1-9.
     
  • Hermann, C., Saccon, R., Senthilan, P. R., Domnik, L., Dircksen, H., Yoshii, T., and Helfrich-Förster, C. (2013) The circadian clock network in the brain of different Drosophila species, J Comp Neurol 521, 367-388.
     
  • Ahmed, Z., and Helfrich-Förster, C. (2013) DroLIGHT: real time embedded system towards endogenous clock synchronization of drosophila. In Front Neuroinform Conference Abstract: Neuroinformatics.
     
  • Kronfeld-Schor, N., Dominoni, D., de la Iglesia, H., Levy, O., Herzog, E. D., Dayan, T., and Helfrich-Forster, C. (2013) Chronobiology by moonlight, Proc R Soc Lond B: Biol Sci 280, 20123088.
     
  • Gmeiner, F., Kołodziejczyk, A., Yoshii, T., Rieger, D., Nässel, D. R., and Helfrich-Förster, C. (2013) GABA(B) receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster, J Exp Biol 216, 3837-3843.
     
  • Ahmed, Z., and Helfrich-F\"orster, C. (2013) DroLIGHT-2: real time embedded and data management system for synchronizing circadian clock to the light-dark cycles, Recent Patents on Computer Science 6, 191-205.
     
  • Hermann, C., Yoshii, T., Dusik, V., and Helfrich-Förster, C. (2012) Neuropeptide F immunoreactive clock neurons modify evening locomotor activity and free-running period in Drosophila melanogaster, J Comp Neurol 520, 970-987.
     
  • Rieger, D., Peschel, N., Dusik, V., Glotz, S., and Helfrich-Förster, C. (2012) The ability to entrain to long photoperiods differs between 3 Drosophila melanogaster wild-type strains and is modified by twilight simulation, J Biol Rhythms 27, 37-47.
     
  • Bywalez, W., Menegazzi, P., Rieger, D., Schmid, B., Helfrich-Förster, C., and Yoshii, T. (2012) The dual-oscillator system of Drosophila melanogaster under natural-like temperature cycles, Chronobiol Int 29, 395-407.
     
  • Kistenpfennig, C., Hirsh, J., Yoshii, T., and Helfrich-Förster, C. (2012) Phase-shifting the fruit fly clock without cryptochrome, J Biol Rhythms 27, 117-125.
     
  • Umezaki, Y., Yoshii, T., Kawaguchi, T., Helfrich-Förster, C., and Tomioka, K. (2012) Pigment-dispersing factor is involved in age-dependent rhythm changes in Drosophila melanogaster, J Biol Rhythms 27, 423--432.
     
  • Vieira, J., Jones, A. R., Danon, A., Sakuma, M., Hoang, N., Robles, D., Tait, S., Heyes, D. J., Picot, M., Yoshii, T., Helfrich-Förster, C., and others,. (2012) Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability, PLoS One 7, e31867.
     
  • Yoshii, T., Rieger, D., and Helfrich-Förster, C. (2012) Two clocks in the brain. In Progress in Brain Research, pp 59-82, Elsevier BV.
     
  • Menegazzi, P., Yoshii, T., and Helfrich-Förster, C. (2012) Laboratory versus Nature The Two Sides of the Drosophila Circadian Clock, J Biol Rhythms 27, 433-442.
     
  • Bartlang, M. S., Neumann, I. D., Slattery, D. A., Uschold-Schmidt, N., Kraus, D., Helfrich-Förster, C., and Reber, S. O. (2012) Time matters: pathological effects of repeated psychosocial stress during the active, but not inactive, phase of male mice, J Endocrinol 215, 425-437.
     
  • Kauranen, H., Menegazzi, P., Costa, R., Helfrich-Förster, C., Kankainen, A., and Hoikkala, A. (2012) Flies in the north: Locomotor behavior and clock neuron organization of Drosophila montana, J Biol Rhythms 27, 377-387.
     
  • Schmid, B., Helfrich-Förster, C., and Yoshii, T. (2011) A new ImageJ plug-in “ActogramJ” for chronobiological analyses, J Biol Rhythms 26, 464-467.
     
  • Helfrich-Förster, C., Nitabach, M. N., and Holmes, T. C. (2011) Insect circadian clock outputs, Essays Biochem 49, 87-101.
     
  • Peschel, N., and Helfrich-Förster, C. (2011) Setting the clock--by nature: circadian rhythm in the fruitfly Drosophila melanogaster, FEBS letters 585, 1435-1442.
     
  • Yoshii, T., Hermann, C., and Helfrich-Förster, C. (2010) Cryptochrome-positive and-negative clock neurons in Drosophila entrain differentially to light and temperature, J Biol Rhythms 25, 387-398.
     
  • Ritz, T., Yoshii, T., Helfrich-Förster, C., and Ahmad, M. (2010) Cryptochrome: A photoreceptor with the properties of a magnetoreceptor?, Commun Integr Biol 3, 24-27.
     
  • Benna, C., Bonaccorsi, S., W\"ulbeck, C., Helfrich-Förster, C., Gatti, M., Kyriacou, C. P., Costa, R., and Sandrelli, F. (2010) Drosophila timeless2 is required for chromosome stability and circadian photoreception, CURR BIOL 20, 346-352.
     
  • Yoshii, T., Ahmad, M., and Helfrich-Förster, C. (2009) Cryptochrome mediates light-dependent magnetosensitivity of Drosophila's circadian clock, PLoS Biol 7, e1000086.
     
  • Kempinger, L., Dittmann, R., Rieger, D., and Helfrich-Förster, C. (2009) The nocturnal activity of fruit flies exposed to artificial moonlight is partly caused by direct light effects on the activity level that bypass the endogenous clock, Chronobiol Int 26, 151-166.
     
  • Helfrich-Förster, C. (2009) Neuropeptide PDF plays multiple roles in the circadian clock of Drosophila melanogaster, Sleep Biol Rhythms 7, 130-143.
     
  • Rieger, D., Wülbeck, C., Rouyer, F., and Helfrich-Förster, C. (2009) Period gene expression in four neurons is sufficient for rhythmic activity of Drosophila melanogaster under dim light conditions, J Biol Rhythms 24, 271-282.
     
  • Yoshii, T., Wülbeck, C., Sehadova, H., Veleri, S., Bichler, D., Stanewsky, R., and Helfrich-Förster, C. (2009) The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock, J Neurosci 29, 2597-2610.
     
  • Helfrich-Förster, C. (2009) Does the morning and evening oscillator model fit better for flies or mice?, J Biol Rhythms 24, 259-270.
     
  • Wülbeck, C., Grieshaber, E., and Helfrich-Förster, C. (2009) Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way, Chronobiol Int 26, 1307-1322.
     
  • Johard, H. A. D., Yoishii, T., Dircksen, H., Cusumano, P., Rouyer, F., Helfrich-Förster, C., and N\"assel, D. R. (2009) Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons, J Comp Neurol 516, 59-73.
     
  • Yoshii, T., Vanin, S., Costa, R., and Helfrich-Förster, C. (2009) Synergic entrainment of Drosophila’s circadian clock by light and temperature, J Biol Rhythms 24, 452-464.
     
  • Yoshii, T., Todo, T., Wülbeck, C., Stanewsky, R., and Helfrich-Förster, C. (2008) Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons, J Comp Neurol 508, 952-966.
     
  • Wülbeck, C., Grieshaber, E., and Helfrich-Förster, C. (2008) Pigment-dispersing factor (PDF) has different effects on Drosophila's circadian clocks in the accessory medulla and in the dorsal brain, J Biol Rhythms 23, 409-424.
     
  • Hamasaka, Y., Rieger, D., Parmentier, M. -L., Grau, Y., Helfrich-Förster, C., and Nässel, D. R. (2007) Glutamate and its metabotropic receptor inDrosophilaclock neuron circuits, J Comp Neurol 505, 32-45.
     
  • W\"ulbeck, C., and Helfrich-F\"orster, C. (2007) RNA in situ hybridizations on Drosophila whole mounts, Circadian Rhythms: Methods and Protocols, Springer 495-511.
     
  • Helfrich-Förster, C. (2007) Immunohistochemistry in Drosophila. In Methods in Molecular Biology, pp 533-547, Springer Nature.
     
  • Rieger, D., Fraunholz, C., Popp, J., Bichler, D., Dittmann, R., and Helfrich-Förster, C. (2007) The fruit fly Drosophila melanogaster favors dim light and times its activity peaks to early dawn and late dusk, J Biol Rhythms 22, 387-399.
     
  • Veleri, S., Rieger, D., Helfrich-Förster, C., and Stanewsky, R. (2007) Hofbauer-Buchner Eyelet Affects Circadian Photosensitivity and Coordinates TIM and PER Expression in Drosophila Clock Neurons, J Biol Rhythms 22, 29-42.
     
  • Bachleitner, W., Kempinger, L., Wülbeck, C., Rieger, D., and Helfrich-Förster, C. (2007) Moonlight shifts the endogenous clock of Drosophila melanogaster, Proc Natl Acad Sci 104, 3538-3543.
     
  • Helfrich-Förster, C., Yoshii, T., Wülbeck, C., Grieshaber, E., Rieger, D., Bachleitner, W., Cusumano, P., and Rouyer, F. (2007) The Lateral and Dorsal Neurons ofDrosophila melanogaster:New Insights about Their Morphology and Function, Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press 72, 517-525.
     
  • Helfrich-Förster, C., Shafer, O. T., Wülbeck, C., Grieshaber, E., Rieger, D., and Taghert, P. (2006) Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster, J Comp Neurol 500, 47-70.
     
  • Shafer, O. T., Helfrich-Förster, C., Renn, S. C. P., and Taghert, P. H. (2006) Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes, J Comp Neurol 498, 180-193.
     
  • Helfrich-Förster, C. (2006) The neural basis of Drosophila’s circadian clock, Sleep Biol Rhythms 4, 224-234.
     
  • Rieger, D., Shafer, O. T., Tomioka, K., and Helfrich-F\"orster, C. (2006) Functional analysis of circadian pacemaker neurons in Drosophila melanogaster, J Neurosci 26, 2531-2543.
     
  • Wülbeck, C., Szabo, G., Shafer, O. T., Helfrich-Förster, C., and Stanewsky, R. (2005) The Novel Drosophila timblind Mutation Affects Behavioral Rhythms but Not Periodic Eclosion, Genetics 169, 751-766.
     
  • Helfrich-F\"orster, C. (2005) Organization of endogenous clocks in insects, Portland Press Limited.
     
  • Helfrich-Förster, C. (2005) PDF has found its receptor, Neuron 48, 161-163.
     
  • Helfrich-Förster, C. (2005) Neurobiology of the fruit fly's circadian clock, Genes Brain Behav 4, 65--76.
     
  • Helfrich-F\"orster, C. (2005) Techniques that revealed the network of the circadian clock of Drosophila, Methods in enzymology, Elsevier 393, 439-451.
     
  • Helfrich-Förster, C. (2004) The circadian clock in the brain: a structural and functional comparison between mammals and insects, J Comp Physiol A 190.
     
  • Veleri, S., Brandes, C., Helfrich-Förster, C., Hall, J. C., and Stanewsky, R. (2003) A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain, Curr Biol 13, 1758-1767.
     
  • Helfrich-Förster, C. (2003) The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster, Microsc Res Tech 62, 94-102.
     
  • Park, J. H., Schroeder, A. J., Helfrich-F\"orster, C., Jackson, F. R., and Ewer, J. (2003) Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior, Development 130, 2645-2656.
     
  • Rieger, D., Stanewsky, R., and Helfrich-Förster, C. (2003) Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster, J Biol Rhythms 18, 377-391.
     
  • Helfrich-F\"orster, C., Edwards, T., Yasuyama, K., Wisotzki, B., Schneuwly, S., Stanewsky, R., Meinertzhagen, I. A., and Hofbauer, A. (2002) The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function, J Neurosci 22, 9255-9266.
     
  • Helfrich-Förster, C. (2002) The circadian system of Drosophila melanogaster and its light input pathways1, Zoology 105, 297-312.
     
  • Helfrich-F\"orster, C., and Engelmann, W. (2002) Photoreceptors for the circadian clock of the fruitfly. In Biological rhythms, pp 94-106, Springer.
     
  • Helfrich-Förster, C., Wulf, J., and De Belle, J. S. (2002) Mushroom body influence on locomotor activity and circadian rhythms in Drosophila melanogaster, J Neurogenet 16, 73-109.
     
  • Helfrich-Förster, C. (2001) The locomotor activity rhythm of Drosophila melanogaster is controlled by a dual oscillator system, J Insect Physiol 47, 877-887.
     
  • Foster, R. G., and Helfrich-Förster, C. (2001) The regulation of circadian clocks by light in fruitflies and mice, Philos Trans R Soc Lond B Biol Sci 356, 1779-1789.
     
  • Helfrich-Förster, C., Winter, C., Hofbauer, A., Hall, J. C., and Stanewsky, R. (2001) The circadian clock of fruit flies is blind after elimination of all known photoreceptors, Neuron 30, 249-261.
     
  • Helfrich-Förster, C., Täuber, M., Park, J. H., M\"uhlig-Versen, M., Schneuwly, S., and Hofbauer, A. (2000) Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster, J Neurosci 20, 3339-3353.
     
  • Helfrich-Förster, C. (2000) Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster-sex-specific differences suggest a different quality of activity, J Biol Rhythms 15, 135-154.
     
  • Park, J. H., Helfrich-Forster, C., Lee, G., Liu, L., Rosbash, M., and Hall, J. C. (2000) Differential regulation of circadian pacemaker output by separate clock genes in Drosophila, Proc Natl Acad Sci 97, 3608-3613.
     
  • Emery, P., Stanewsky, R., Helfrich-Förster, C., Emery-Le, M., Hall, J. C., and Rosbash, M. (2000) Drosophila CRY is a deep brain circadian photoreceptor, Neuron 26, 493-504.
     
  • Hao, H., Glossop, N. R. J., Lyons, L., Qiu, J., Morrish, B., Cheng, Y., Helfrich-Förster, C., and Hardin, P. (1999) The 69 bp Circadian Regulatory Sequence (CRS) Mediatesper-Like Developmental, Spatial, and Circadian Expression and Behavioral Rescue in Drosophila, J Neurosci 19, 987-994.
     
  • Helfrich-Förster, C. (1998) Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants, J. Comp. Physiol. A 182, 435-453.
     
  • Antkowiak, B., and Helfrich-Förster, C. (1998) Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons In vitro, Anesthesiology 88, 1592-1605.
     
  • Helfrich-Förster, C. (1997) Development of pigment-dispersing hormone-immunoreactive neurons in the nervous system of drosophila melanogaster, J Comp Neurol 380, 335-354.
     
  • Kaneko, M., Helfrich-F\"orster, C., and Hall, J. C. (1997) Spatial and temporal expression of the period andtimeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling, J Neurosci 17, 6745-6760.
     
  • Helfrich-Förster, C. (1995) The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster., Proc Natl Acad Sci 92, 612-616.
     
  • Helfrich-Förster, C., and Homberg, U. (1993) Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity, Journal of Comparative Neurology, Wiley-Blackwell 337, 177-190.
     
  • Helfrich, C., and Engelmann, W. (1987) Evidences for circadian rhythmicity in the per0 mutant of Drosophila melanogaster, J Biosci 42, 1335-1338.
     
  • Helfrich, C. (1986) Role of the Optic Lobes in the Regulation of the Locomotor Activity Rhythm of Drosophila melanogaster: Behavioral Analysis of Neural Mutants, J Neurogenet 3, 321-343.
     
  • Helfrich, C., Cymborowski, B., and Engelmann, W. (1985) Circadian activity rhythm of the house fly continues after optic tract severance and lobectomy, Chronobiol Int 2, 19-32.
     
  • Helfrich-Förster, C., and Engelmann, W. (1983) Circadian rhythm of the locomotor activity in Drosophila melanogaster and its mutants ‘sine oculis’ and ‘small optic lobes’, Physiol Entomol 8, 257-272.
     

Ältere Artikel

1983 - 2008

Buchbeiträge (peer reviewed)

  • Helfrich-Förster C and Engelmann W (2002) Photoreceptors for the circadian clock of the fruit fly. In: Circadian Rhythms (V. Kumar, ed.), Narosa Publishing House, 94-106.
  • Helfrich-Förster C (2006) Immunohistochemistry in Drosophila, sections and whole mount. In: Methods in Molecular Biology, Volume 362, 533-547.
  • Wülbeck C and Helfrich-Förster C (2006) RNA In Situ hybridizations on Drosophila whole mounts. In: Methods in Molecular Biology, Volume 362, 495-511.
  • Helfrich-Förster C, Yoshii T, Wülbeck C, Grieshaber E, Rieger D, Bachleitner B, Cusamano P, Rouyer F (2007) The Lateral and Dorsal Neurons of Drosophila melanogaster: New insights about their morphology and function. In: Clocks and Rhythms, Cold Spring Harbor Laboratory Press, 517-525.
  • Yoshii T, Rieger D, Helfrich-Förster C (2012) Two clocks in the brain – an update of the Morning and Evening oscillator model in Drosophila. In: In Andries Kalsbeek, Martha Merrow, Till Roenneberg and Russell G. Foster, editors: Progress in Brain Research, Vol. 199, Neurobiology of Circadian Timing. Amsterdam, The Netherlands, pp. 59-82.
  • Johnsson A, Helfrich-Förster C, Engelmann W (2015) How light resets circadian clocks. In Photobiology. The Science of Light and Life. Editor: Lars Olof Björn. Third edition. Springer, New York, pp 243-297.

Sonstige

  • Förster C (2009) Macht die innere Uhr “mondsüchtig”? BIOspektrum 5, 491-492.
  • Helfrich-Förster C (2010) Das neuronale Netzwerk der Inneren Uhr. Neuroforum 1/10, 151-156.
  • Helfrich-Förster (2015) Die Innere Uhr von Mensch und Tier. In Blickpunkt: Zeit. Die (un)ermessliche Dimension? (Hrsg: E.A. Herzog, H.-C. Bauer, K. P Überriegler), Books on demand. pp: 89-107. ISBN 9783734 785986.